PMID

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Article Title

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Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

National University of Singapore

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.

West China Hospital of Sichuan University

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

University of Milan

Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.

Sungkyunkwan University

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.

Sichuan University

Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.

Orchid Chemicals & Pharmaceuticals

Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.

University of Minnesota

Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.

Guangzhou Institute of Biomedicine and Health

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

University of Minnesota

Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.

University College London

Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).

St. Jude Children'S Research Hospital

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.

University of Florida

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.

Istituto Ortopedico Rizzoli (Ior)

Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.

H�Pital Kirchberg

Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.

R&D Sigma-Tau Industrie Farmaceutiche Riunite

Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.

TBA

Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.

Technical University of Denmark

Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.

Roche Pharmaceutical Research and Early Development

ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.

R&D Sigma-Tau Industrie Farmaceutiche Riunite

Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.

Chinese Academy of Sciences

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.

Taipei Medical University

Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.

Universit£

4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.

Universit£

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.

Universit£

Development of a chimeric c-Src kinase and HDAC inhibitor.

University of Michigan

Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.

Roche R & D Center China

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

University of Illinois At Chicago

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Kyoto Prefectural University of Medicine

Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.

Guru Ghasidas University

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR.

TBA

Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.

University of Illinois At Chicago

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.

S*Bio

Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.

Universita` Degli Studi Di Siena

Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity

TBA

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

The Scripps Research Institute

Design and synthesis of novel isoxazole-based HDAC inhibitors.

Università

Inside HDAC with HDAC inhibitors.

Universit£

Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.

S*Bio

Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.

University of Illinois At Chicago

Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.

Curis

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

Ortho-Biotech Oncology Research & Development

Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.

Sigma-Tau Research and Development

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.

University of Illinois At Chicago

N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.

R&D Sigma-Tau

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

S*Bio

Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

University of Illinois At Chicago

Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.

University of Illinois At Chicago

Inside HDACs with more selective HDAC inhibitors.

Universit£

Histone deacetylase 3 (HDAC3) inhibitors as anticancer agents: A review.

Jadavpur University

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).

"Sapienza" University of Rome

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity.

Northwest A&F University

Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.

Scripps Research

Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.

South China University of Technology

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.

Menoufia University

Discovery of HDAC6-Selective Inhibitor NN-390 with

University of Toronto Mississauga

Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy.

Stony Brook University

Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapy.

Shanghai Institute of Pharmaceutical Industry

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.

University of Toronto Mississauga

Comparison of three zinc binding groups for HDAC inhibitors - A potency, selectivity and enzymatic kinetics study.

Ocean University of China

Molecular design of dual inhibitors of PI3K and potential molecular target of cancer for its treatment: A review.

Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity.

Shandong University

Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.

University of Siena

Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.

China Pharmaceutical University

Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent.

Taipei Medical University

Histone deacetylase 2: A potential therapeutic target for cancer and neurodegenerative disorders.

Nirma University

A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity.

Zhengzhou University

Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.

Ocean University of China

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.

University of Toronto Mississauga

Discovery of Novel Pyrrolo[2,3-

Chinese Academy of Sciences

Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A

Shanghaitech University

Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC).

China Pharmaceutical University

Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.

West China Hospital of Sichuan University

Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease.

Shandong University

Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.

Shandong University

Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.

Children'S Hospital Affiliated To Zhengzhou University

Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.

Italfarmaco

Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy.

Second Military Medical University

Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.

Nankai University

Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer.

Shenzhen Technology University

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.

University of East Anglia

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.

Taipei Medical University

CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition.

Taipei Medical University

Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.

Merck

Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma.

Jubilant Therapeutics India

PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia.

University of Toronto Mississauga

Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.

A*Star

Recent advances in the discovery of potent and selective HDAC6 inhibitors.

Shandong University

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.

Sichuan University

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.

Sichuan University

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.

University of Toronto Mississauga

Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.

University of Connecticut

A novel class of anthraquinone-based HDAC6 inhibitors.

Keimyung University

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.

Indian Csir-Central Drug Research Institute

Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.

TBA

Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.

National Center For Advancing Translational Sciences

Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides.

Jadavpur University

Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.

Umr Cnrs 7285

Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors.

Northwest A&F University

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.

European Molecular Biology Laboratory

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.

Taipei Medical University

Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.

University of Toronto Mississauga

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.

Taipei Medical University

Recent advances in class IIa histone deacetylases research.

Heinrich-Heine-Universit£T D£Sseldorf

Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.

Sichuan University and Collaborative Innovation Center of Biotherapy

Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.

Chinese Academy of Sciences

Discovery of Thieno[2,3-

Sichuan University and Collaborative Innovation Center of Biotherapy

Indole: A privileged scaffold for the design of anti-cancer agents.

Hunan University of Science and Technology

Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.

Qingdao University

Highly fluorescent and HDAC6 selective scriptaid analogues.

Deakin University

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.

National University of Singapore

Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.

Shandong University

Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors.

Universit£

Design and biological evaluation of tetrahydro-?-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.

University of Regensburg

Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors.

Universit£

Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.

Nestle Skin Health R&D

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Kansai University

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.

Taipei Medical University

Discovery of a fluorescent probe with HDAC6 selective inhibition.

Shandong University

Designing multi-targeted agents: An emerging anticancer drug discovery paradigm.

Hunan University of Chinese Medicine

Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.

Forma Therapeutics

Exploring Derivatives of Quinazoline Alkaloid l-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors.

Csir-Indian Institute of Integrative Medicine

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.

University of Regensburg

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity.

Taipei Medical University

Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD).

Universit£

Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.

Ghent University

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.

National University of Singapore

Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.

Novartis Institutes For Biomedical Research

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.

Taipei Medical University

Synthesis and biological evaluation of largazole zinc-binding group analogs.

Duke University

The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.

Soochow University

Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.

Genentech

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.

Friedrich Miescher Institute For Biomedical Research

Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.

University of Florida College of Medicine

CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.

Celera Genomics

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.

University of Illinois At Chicago